In vivo and in vitro correlation of azithromycin cationic micron niosomes
10.3969/j.issn.1001-1978.2017.12.017
- VernacularTitle:阳离子阿奇霉素微类脂体体内外相关性
- Author:
Mei ZENG
1
;
Meng ZHONG
;
Yue FENG
;
chun Jian LUO
;
rao Qi ZHANG
;
qing Jing ZHANG
Author Information
1. 重庆医科大学药学院药物高校工程研究中心
- Keywords:
azithromycin;
micron niosomes;
pharma-cokinetics;
Wagner-Nelson method;
deconvolution method;
in vitro and in vivo correlation
- From:
Chinese Pharmacological Bulletin
2017;33(12):1713-1717
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the correlation between in vitro release and in vivo absorption of azithromycin cat-ionic micron niosomes (ACMNS)by Wagner-Nelson method and deconvolution method. Methods The in vitro release behavior of ACMNS was studied by dy-namic membrane dialysis. After a single dose of intra-gastric administration with ACMNS and AM in rats,the AM concentrations in plasma were determined by high performance liquid chromatography(HPLC). Wagner-Nelson and deconvolution method were used to reveal the in vitro / in vivo correlation. Results X used as cu-mulative in vitro release and Fa as the absorption per-centage,the regression equation was established:F a =3. 0524X - 5. 7709,r = 0. 8976,and X used as cumu-lative in vitro release and R as input function,the re-gression equation was established:R = 2. 3413X -58. 687,r = 0. 5217. r < r( 2,0. 05) = 0. 9500 (P <0. 05). Conclusion There is no correlation between in vitro release and in vivo absorption of ACMNS.
