Effects of curcumol on contraction of duodenal smooth muscle in rats
10.3969/j.issn.1001-1978.2017.12.018
- VernacularTitle:莪术醇对大鼠十二指肠平滑肌收缩的影响
- Author:
Long JIN
1
;
xiu Jian MA
;
qing Yan MA
Author Information
1. 西北民族大学医学院
- Keywords:
curcumol;
duodenal smooth muscle;
M receptor;
β receptor;
α receptor;
Ca2 +;
rats
- From:
Chinese Pharmacological Bulletin
2017;33(12):1717-1720
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of curcumol on the contractile activity of isolated duodenal smooth muscle in rats and explore its underlying mechanisms. Methods The isolated duodenum specimens of rats were made. The effects of different concentrations of curcumol on the contraction of isolated duodenal smooth muscle were observed using BL-420F biological and functional experimental system with constant tem-perature perfusion method. A certain concentration of curcumol was combined with atropine,isoproterenol, norepinephrine,calcium-free Krebs solution,verapam-il respectively to observe its effect on smooth muscle contraction. Results Curcumol could stimulate duo-denal smooth muscle in vitro,and increase its contrac-tile amplitude and tension significantly. It could be an-tagonized partly by atropine,isoprenaline,norepineph-rine,verapamil. Conclusion Curcumol can promote the contraction of isolated duodenal smooth muscle in rats,which may be achieved by stimulating M recep-tor,inhibiting α and β receptors,and promoting the extracellular calcium influx.
