Expression of CD44, TRIM24, TAGLN-2, ER and PR in breast invasive ductal carcinoma and their clinicopathologic significance
10.13315/j.cnki.cjcep.2017.07.004
- VernacularTitle:乳腺浸润性导管癌中CD44、TRIM24、TAGLN-2、ER、PR的表达及其临床意义
- Author:
bo Qing ZHANG
1
;
gui Mei LU
;
fu Bao XU
;
Shuan WANG
;
Li ZHAO
;
xia Qiao ZHOU
;
He YAN
;
qun Chao WANG
;
jun Fei HUANG
Author Information
1. 四川大学华西基础医学与法医学院法医病理教研室
- Keywords:
breast neoplasm;
invasive ductal carcinoma;
CD44;
TRIM24;
TAGLN-2;
ER;
PR;
clinicopathology
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(7):724-727
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of biomolecules of PI3K-AKT signaling pathway including CD44,TRIM24,TAGLN-2,ER and PR in breast invasive ductal carcinoma,and to explore their clinicopathologic significance.Methods The expression of CD44,TRIM24,TAGLN-2,ER and PR in 73 cases of breast invasive ductal carcinoma were detected by immunohistochemist~ (IHC) technology.And the relationship between the expression of these biomarkers and the age of patients,tumor size,histological grade,lymph node metastasis was analyzed.Besides,the influence of these biomarkers on prognosis and the relationship between the expression of these biomarkers were also analyzed.Results There was no significant relationship between the expression of these biomarkers and the age of patients,tumor size,histological grade,lymph node metastasis.CD44 expression was positively conelated with TAGLN-2 expression (r =0.311,P =0.007),TRIM24 expression was positively correlated with TAGLN-2 expression (r =0.421,P =0.000).CD44 expression was negatively correlated with ER expression (r =-0.285,P =0.015).ER expression was positively correlated with PR expression (r =0.598,P =0.000).The postoperative 5-year cumulative survival-rate of CD44 positive group was lower than those of CD44 negative group (P =0.002),in contrast,the postoperative 5-year survival rate of ER positive group was higher than those of ER negative group (P =0.026).Conclusion Through PI3K-AKT signaling pathway,CD44 and TRIM24 may up-regulate TAGLN-2 expression,however,CD44 may down-regulate ER and PR expression.CD44 and ER may act an useful predictor for the prognosis of breast invasive ductal carcinoma.Combined detection of CD44,ER and PR may provide additional therapeutic information which may be useful in breast cancer treatment.
