The effects of vorinostat on erlotinib-resistance of lung adenocarcinoma cells
10.19405/j.cnki.issn1000-1492.2017.10.018
- VernacularTitle:伏立诺他对肺腺癌厄洛替尼耐药细胞株耐药性的影响
- Author:
Pengfei WU
1
;
Jiqing HAO
Author Information
1. 安徽医科大学第一附属医院肿瘤内科
- Keywords:
lung adenocarcinoma;
histone deacetylase inhibitor;
vorinostat;
erlotinib;
drug resistance
- From:
Acta Universitatis Medicinalis Anhui
2017;52(10):1500-1503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of vorinostat(SAHA) on the erlotinib-resistance of human lung adenocarcinoma cell line PC-9/ER.Methods PC-9/ER cells were treated with erlotinib and SAHA,alone or in combination.The effects of proliferation inhibition were assayed by MTT method,the apoptosis ratios of cells were analyzed by flow cytometry.Results The results showed that SAHA inhibited the proliferation of PC-9/ER cells in a dose-dependent manner alone.The non-toxic doses of SAHA (1 μmol/L) significantly improved the sensitivity of PC-9/ER to Erlotinib,and induce apoptosis.Conclusion SAHA could partially improve PC-9/ER sensitivity to erlotinib.
