Correlation Study Between Plasma microRNA-1, microRNA-146b Expressions and Diagnosis, Prognosis of Acute ST-segment Elevation Myocardial Infarction
10.3969/j.issn.1000-3614.2017.11.005
- VernacularTitle:血浆微小核糖核酸-1和微小核糖核酸-146b表达水平与急性ST段抬高型心肌梗死诊断及预后的相关性研究
- Author:
ting Ting LI
1
;
feng De PAN
;
Hong ZHU
Author Information
1. 徐州医科大学附属医院 心内科
- Keywords:
Myocardial infarction;
MicroRNAs;
Prognosis
- From:
Chinese Circulation Journal
2017;32(11):1060-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of plasma microRNA-1 (miR-1) and microRNA-146b (miR-146b) at the early stage of acute ST-segment elevation myocardial infarction (STEMI) and to explore the relationship between miR-1, miR-146b and STEMI diagnosis, prognosis in relevant patients. Methods: Our research included in 2 groups: STEMI group, n=47 patients and Control group, n=23 healthy subjects. Blood samples were taken at immediate admission, 12 h of onset (T12), T24, T48, T72 and T1w (1 week of onset), plasma levels of miR-1, miR-146 and cardiac troponin (cTnT) were examined at different time points and compared between 2 groups. The value of miR-1, miR-146b on STEMI diagnosis was assessed by ROC curve; relationship between plasma levels of miR-1, miR-146 and CRP, BNP, WBC count at immediate admission was evaluated. All patients were followed-up for major adverse cardiac events (MACE) within 1 month of diagnosis; the impact of miR-1, miR-146 at peak time on 30-d cumulative survival rate was analyzed.Results: Compared with Control group, STEMI group had increased plasma levels of miR-1 and miR-146b at immediate admission, T12, T24, T48; elevated cTnT at immediate admission, T12, T24, T48 and T72, all P<0.05. At immediate admission, the area of miR-1 and miR-146b under ROC curve for STEMI diagnosis were 0.800 and 0.789, both P<0.001; miR-146b was positively related to CRP, BNP and WBC count, all P<0.05. Cumulative survival rate in patients with high expressions of miR-1, miR-146 at peak time was lower than those with low expressions of miR-1, miR-146, all P<0.05. Conclusion: Plasma levels of miR-1 and miR-146b might be become the biomarkers for early STEMI diagnosis; miR-1 and miR-146b were related to STEMI prognosis in relevant patients.
