Research progress of reversion molecular targeted drug resistance in non-small cell lung cancer by curcumin
10.3969/j.issn.1001-1978.2017.12.002
- VernacularTitle:姜黄素逆转非小细胞肺癌分子靶向药物耐药的研究进展
- Author:
di Meng YU
1
;
xia Ming WANG
;
dong Hai WANG
Author Information
1. 河北医科大学第四医院药学部
- Keywords:
molecular targeted drug;
drug resistance;
non-small-cell lung cancer(NSCLC);
curcumin;
resistance mecha-nism;
reversion resistance
- From:
Chinese Pharmacological Bulletin
2017;33(12):1633-1637
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,molecular biology has rapidly devel-oped,and molecular targeted therapy of non-small cell lung cancer has become a hot spot for the research. Although the tar-geted therapy has a big advantage compared with traditional chemotherapy,it is inevitable to encounter drug resistance in targeted therapy. Therefore,drug resistance has become the sig-nificant obstacle of targeted drugs for the treatment of non-small-cell lung cancer(NSCLC). Curcumin is the main extract of tu-meric rhizome,which harbours a wide range of antitumor activi-ties,and several studies have identified that curcumin exhibits reversion drug resistance against a variety of cancer cells. How-ever,there are few studies on curcumin reversion molecular tar-geted drug resistance. This review summarizes the recent pro-gress in resistance mechanism of targeted drug and the reversion resistance of curcumin.
