Study of active ingredients of Chinese medicine interfering with molecular signaling pathway of liver fibrosis
10.3969/j.issn.1001-1978.2017.12.003
- VernacularTitle:中药活性成分干预肝纤维化分子信号通路的研究进展
- Author:
feng Chuan XUAN
1
;
sheng Wei LUO
;
zhong Guo CHEN
;
yu Zhuo PENG
;
Yi KANG
;
Rui HUANG
;
wu Yang ZHANG
Author Information
1. 广西中医药大学第一临床医学院
- Keywords:
hepatic fibrosis;
p38MAPK;
TGF-β/ Smad;
Ras/ERK;
Hedgehog;
Hedgehog;
active ingredient of TCM
- From:
Chinese Pharmacological Bulletin
2017;33(12):1638-1641
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and progression of hepatic fibrosis are regulated by multicytokines and multiple molecular signal trans-duction pathways in cells. Currently,the molecular signaling pathway is the target for drugs to treat diseases. The study of the active ingredients of Chinese medicine to interfere with the sig-naling pathways of liver fibrosis is a hot topic. In the past ten years,it has been reported that hydroxysafflor yellow A,total flavonoids from litchi seed,ursolic acid,curcumin can interfere the signaling pathway of p38MAPK,TGF-β/ Smad,Wnt,Ras/ERK and Hedgehog liver fibrosis. The research on the active in-gredients of Chinese traditional medicine,which is targeted at signaling pathways,is expected to open new areas for Chinese and western medicine in the treatment of liver fibrosis.
