Expression of HIF-1α and BCL-2 in salivary adenoid cystic carcinoma and its clinical significance
10.13315/j.cnki.cjcep.2017.07.005
- VernacularTitle:涎腺腺样囊性癌中HIF-1α和BCL-2的表达及意义
- Author:
gang He BAO
1
;
Liang XIAO
;
Gang MENG
;
jun Yue WANG
;
Feng WANG
;
sen Wen JIN
Author Information
1. 安徽医科大学核医学教研室
- Keywords:
salivary neoplasm;
adenoid cystic carcinoma;
HIF-1 α;
BCL-2;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(7):728-732
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relationship of HIF-1α,BCL-2 and clinicopathological features in salivary adenoid cystic carcinoma by detecting the levels of two proteins.Methods Immunohistochemical of SP staining assay was used to detect the level of HIF-1α and BCL-2 expression in fifty-six section from primary resection of salivary adenoid cystic carcinoma.Furthermore,the correlation between the expressions of two proteins with clinical data was evaluated through differently statistical analysis.Results Thirty-six samples (64.3％) were found to express HIF-1α.The level of HIF-1α was significantly correlated with TNM stage of tumors and the primary site of salivary adenoid cystic carcinoma (P ＜ 0.05).Positive BCL-2 expression was detected in fifty-five cases (98.2％).The level of HIF-1 α was positively correlated with that of BCL-2 (P ＜ 0.05)and the significant correlation between HIF-1α and TNM stage was dependent upon the strong expression of BCL-2 (P ＜ 0.05).Conclusion It is therefore indicated that the expression of HIF1α and BCL-2 may influence the clinical stage of salivary adenoid cystic carcinoma.
