Expression and Clinical Significance of Serum Long Chain Non-encoded RNA ANRIL in Chronic Heart Failure Patients
10.3969/j.issn.1000-3614.2017.11.012
- VernacularTitle:位于细胞周期激酶抑制因子4基因座中反义非编码RNA在慢性心力衰竭患者血清中的表达及临床意义
- Author:
zhong Min FEI
1
;
ling Ling CHEN
;
ling Mei ZHANG
;
Ping OUYANG
Author Information
1. 上海市松江区中心医院 心血管内科
- Keywords:
Gene expression;
Heart failure
- From:
Chinese Circulation Journal
2017;32(11):1095-1098
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expression and clinical significance of serum long chain non-encoded RNAANRIL (LncRNA ANRIL) in chronic heart failure (CHF) patients. Methods: Our research included in 2 groups: CHF group, n=120 patients treated in our hospital and Control group, n=28 healthy subjects at the same period of time. Based on NYHA classification, CHF patients were further divided into 4 subgroups: NYHAⅠ subgroup, n=28, NYHA Ⅱ subgroup, n=34, NYHA Ⅲ subgroup, n=35 and NYHA Ⅳ subgroup, n=23. Expressions of serum ANRIL and cystatin C were examined by real time fluorescence quantitative PCR (QRT-PCR) and compared between 2 groups; the relationship between ANRIL, cystatin C and cardiac function were studied. Results: Compared with Control group, CHF group had increased serum levels of ANRIL and cystatin C, P<0.05. ANRIL expression was gradually increasing by cardiac function decreasing in CHF I to CHF Ⅳ subgroups, P<0.05. Correlation analysis found that serum level of ANRIL was positively related to cystatin C (r=0.873, P<0.001). ANRIL was elevated by increased left ventricular end diastolic diameter and decreased ejection fraction, both P<0.05. Conclusion: Serum ANRIL level has been related to CHF at certain degree which may indirectly reflect the severity of HF in relevant patients.
