Influence of acupuncture combined with enema on uterine hemodynamics and HMGB1, TLR4 in the patients with acute pelvic inflammatory
10.3760/cma.j.issn.1673-4246.2017.11.008
- VernacularTitle:针灸联合中药保留灌肠对急性盆腔炎患者子宫血流动力学及血清高迁移率族蛋白1与toll样受体4水平的影响
- Author:
Huijuan CHENG
1
;
Yongfen TU
Author Information
1. 湖北省中西医结合医院妇科
- Keywords:
Pelvic inflammatory disease;
Acute disease;
Hemodynamics;
High mobility group proteins;
TLR4
- From:
International Journal of Traditional Chinese Medicine
2017;39(11):989-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of acupuncture combined with enema in the treatment of acute pelvic inflammatory, and its effects on uterine hemodynamics and seurm levels of high mobility group box-1 protein (HMGB1), toll-like receptor 4 (TLR4). Methods A total of 66 patients with acute pelvic inflammatory were enrolled in the study, randomly divided into the combination treatment group (n=33) and conventional treatment group (n=33). The patients in the combination treatment group were given with acupuncture combined with enema on the basis of conventional therapy. After 10 d treatment, the effective rate was observed. The changes of serum HMGB1 and TLR4 were compared and analyzed. Results After 10 d treatment, the total effective rate was 90.91% (30/33) in the combination treatment group, and 69.70% (23/33) in the conventional treatment group. There were statistically significant differences between the two groups (χ2=8.246,P<0.05).After treatment,the left Vmax(39.16 ± 0.73 cm/s vs.35.47 ± 0.83 cm/s),right Vmax(41.23 ± 1.12 cm/s vs.36.24 ± 0.75 cm/s),left PI(2.23 ± 0.25 cm/s vs.3.11 ±0.45 cm/s),right PI(2.17 ± 0.22 cm/s vs. 2.62 ± 0.23 cm/s),left RI(0.48 ± 0.08 cm/s vs.0.73 ± 0.13 cm/s)and right RI(0.43 ± 0.11 cm/s vs.0.71 ± 0.16 cm/s)of the combined treatment group were significantly superior to the conventional treatment group (all P<0.01). The levels of serum HMGB1(17.45 ± 5.01 ng/ml vs.21.32 ± 6.15 ng/ml,t=2.803)and TLR4(1.05 ± 0.64 ng/ml vs. 1.75 ± 0.91 ng/ml, t=3.614) in the combination treatment group were significantly lower than those in conventional treatment group (all P<0.01). Conclusions Acupuncture combined with traditional Chinese medicine enema treatment of acute pelvic inflammatory disease is better, improve the uterine hemodynamics. The mechanism may be related to inhibit the release of HMGB1, TLR4 and its induced inflammatory response.
