Association of Single Nucleotide Polymorphisms of Autophagy-related Genes Atg7 Site rs11706903 and Parkin-son's Disease

VernacularTitle:自噬相关基因Atg7 rs11706903单核苷酸多态性与帕金森病的相关性
Author: Peng HE ¹ ; yao Xi ZHAO ; sen Yu CHEN ; yi Xiao CHEN ; ming Wei ZHENG
Author Information

1. 广东省人民医院南海医院(佛山市南海区第二人民医院)神经内科
Keywords: Parkinson's disease; autophagy-related genes; intron; single nucleotide polymorphisms; rs11706903
From: Chinese Journal of Rehabilitation Theory and Practice 2017;23(11):1313-1316
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the single nucleotide polymorphisms(SNP)of rs11706903,intron region of Atg7,and Parkinson's disease(PD).Methods From January,2013 to March,2017,130 PD patients and 109 healthy subjects were recruit-ed and collected the blood samples.SNPs of rs11706903 were detected with polymerase chain reaction restriction fragment length polymor-phism.Results For the patients,the genotype frequencies of rs11706903 were AA 10.00%,AC 52.31% and CC 37.69%;and allele frequen-cies were A 36.15% and C 63.85%.For the healthy controls,the genotype frequencies of rs11706903 were AA 7.34%,AC 49.54% and CC 43.12%;and allele frequencies were A 32.11% and C 67.89%.There was no significant difference in frequencies of genetypes and alleles be-teen two groups(χ 2<1.001,P>0.05).Conclusion There might be no relationship between SNPs of Atg7 intron region rs11706903 and PD.