Distribution of missense mutation rs20541C/T polymorphism of interleukin-13 gene in Guangxi population
10.3969/j.issn.1000-484X.2017.11.017
- VernacularTitle:白细胞介素-13基因错义突变rs20541C/T多态性在广西人群中的分布
- Author:
Rong WANG
1
;
Lan Yu LU
;
Tuo Hua HUANG
;
Mei Hai QIN
;
Yan LAN
;
Li Jun WANG
;
Hong Chun LIU
;
Sheng Ye WEI
Author Information
1. 右江民族医学院附属医院检验科
- Keywords:
IL-13 gene;
Polymorphism;
Missense mutation;
Ethnic
- From:
Chinese Journal of Immunology
2017;33(11):1682-1684,1688
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the distribution characteristics of IL-13 gene rs20541C/T site polymorphism in Guangxi population and compare the distribution differences among different populations.Methods: IL-13 genotypes were examined by using SNaPshot technique and DNA sequencing in 275 Guangxi people and analyzed the distribution frequencies of allele and genotype in this site.The result compared with the allele and genotype of other populations(Europeans,Beijingers,Japanses and Africans).Results:The polymorphism of rs20541C/T of IL-13 gene in Guangxi population existed.The genotype frequencies of CC,CT and TT were 40.0%,46.2% and 13.8% respectively.The frequencies of C and T allele were found to be 63.1% and 36.9%.The polymorphism had no significant difference between male and female(P>0.05).Compared rs20541C/T of IL-13 gene with those of HapMap-CEU, HapMap-YRI and Tianjin people,the distribution frequency of genotypes was significantly different(P<0.05).In this site,there were significant differences of allele frequency when compared with the other five populations(P<0.05).Conclusion: There are different degrees of diversity of rs20541C/T polymorphism of IL-13 gene among different races and regions.
