Progress in α5GABAA receptors and their allosteric modulators in learning-memory
10.3867/j.issn.1000-3002.2017.07.010
- VernacularTitle:α5GABAA受体及其变构调节剂对学习记忆功能作用的研究进展
- Author:
fang Zi ZHAO
1
;
Teng GAO
;
qing Yi YIN
Author Information
1. 中日友好医院手术麻醉科
- Keywords:
Alpha 5 subunit-containingγ-aminobutyric acid type A receptors;
hippocampus;
cogin-tion;
learning-memory;
modulators
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(7):766-771
- CountryChina
- Language:Chinese
-
Abstract:
Alpha 5 subunit-containing γ-aminobutyric acid type A receptors (α5GABAARs), mainly distributed in the hippocampus, are an inhibitory synaptic receptor of the central nervous system.α5GABAARs inhibit the hippocampal neurons by mediating a chloride leak current. A number of studies have demonstrated that alterations in the level of excitability of α5GABAARs impair cognitive function and learning-memory, thus resulting in a series of diseases and symptoms including postoperative cognitive dysfunction, pain, depression, schizophrenia and Down syndrome. Accordingly, allosteric modulators for α5GABAARs show therapeutic or improving effects on the above clinical diseases. This review mainly discusses the physiology of α5GABAARs, impact on cognition and key effects of these allosteric modulators.
