Association between Hp infection and insulin resistance in vascular dementia patients
10.3969/j.issn.1009-0126.2017.11.006
- VernacularTitle:血管性痴呆患者幽门螺杆菌感染和胰岛素抵抗的相关性研究
- Author:
xue Ke LUO
1
;
Jie BIAN
Author Information
1. 浙江省立同德医院干部保健科
- Keywords:
dementia,vascular;
helicobacter pylori;
insulin resistance;
coronary disease;
brain infarction
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2017;19(11):1142-1144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of Hp infection and insulin resistance (IR) with vascular dementia (VaD).Methods Eighty-six elderly VaD patients admitted to our hospital from April 2015 to April 2016 served as a VaD group and 52 healthy subjects undergoing physical examination served as a control group in this study.The patients in VaD group were further divided into Hp-positive group (n =50) and Hp-negative group (n =36).Their fasting blood glucose (FBG) and fasting insulin (FINS) levels were measured with positive C13 urea breath test as the diagnostic index of Hp infection.HOMA-IR=FINS× FBG/22.5 was calculated according to the self balance model analysis.Results The positive Hp rate,serum FBG and FINS levels,and HOMA-IR were significantly higher in VaD group than in control group (58.14％ vs 28.58％,x2=10.273,P=0.002;5.53±0.60 mmol/L vs 5.19±0.38 mmol/L,P=0.0004;10.29±4.95 μIU/L vs 8.77±4.02 μIU/L,P=0.0317;2.57±1.34 vs 2.06±0.96,P=0.0179).The serum FBG and FINS levels and HOMA-IR were significantly higher in Hp-positive group than in Hp-negative group (P＜0.05,P＜0.01).Conclusion Hp infection and IR are closely associated with VaD,and can thus lead to the occurrence or progression of VaD by inducing or aggravating IR.
