Improving Effect of Curcumin Analogue H8 on Glucose and Lipid Metabolism Disorder in db/db Mice
10.3870/j.issn.1004-0781.2017.12.005
- VernacularTitle:姜黄素及其类似物H8改善db/db小鼠糖脂代谢紊乱
- Author:
Xiaojin ZHAO
1
;
Lingyu LI
;
Li LI
;
Chunyin TANG
;
Hongzhi LI
;
Jieting LIU
;
Chunlei ZHANG
;
Yan WU
;
Xiaohuan YUAN
Author Information
1. 牡丹江医学院医药研究中心
- Keywords:
Curcumin analogues H8;
Diabetes mellitus;
Glucose metabolism disorders
- From:
Herald of Medicine
2017;36(12):1354-1358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of curcumin and its analogue H8 on glucose and lipid metabolism disorder in db/db mice. Methods The type 2 diabetes mouse model (db/db mice) was intragastrically administrated with curcumin and analogue H8 for 8 weeks.The blood biochemical indexes were measured.The expression of PEPCK and G6Pase mRNA was detected by real-time PCR in liver tissues.The expression of PEPCK and G6Pase protein was detected by Western blotting. Results Curcumin analogue H8 reduced blood glucose and lipids in db/db mice (P<0.01) and improved liver function related enzymes significantly.The levels of PEPCK and G6Pase mRNA in db/db mice were significantly decreased (P<0.01) and the expression levels of PEPCK and G6Pase protein were significantly decreased(P<0.01). Conclusion Curcumin analogue H8 improves the glucose and lipid metabolism disorder in db/db mice,and it is related to inhibiting the expression of PEPCK and G6Pase gene and protein.
