Protective Effects of Xuemailing on Acute Myocardial Ischemia in Rats
10.3870/j.issn.1004-0781.2017.12.006
- VernacularTitle:血脉灵组方对急性心肌缺血大鼠的保护
- Author:
Jian LEI
1
;
Guangli TAO
Author Information
1. 第三军医大学新桥医院药学部
- Keywords:
Xuemailing;
Pituitrin;
Ischemia;
myocardial
- From:
Herald of Medicine
2017;36(12):1359-1362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of Xuemailing on pituitrin-induced myocardial rats. Methods The rats were divided into 7 groups(by means of random number table), 10 rats in each group, namely blank control group, model control group,Di'aoxinxuekang group and experimental groups(Xuemailing prepared fleece flower root high and low dose groups;Xuemailing raw radix polygoni multiflori high and low dose groups), each group was ig administrated once every day for 7 days, Blank control and model control groups were given the same volume of purified water.Effects of 7 groups on T wave and S-T segment were observed,LDH,CK,SOD,MDA activities in serum of rats were determined. Results High dose Xuemailing (prepared fleece flower root) significantly decreased the elevation of 10,30,45 s,1 min ST segment and 10,30,45 s T wave in the myocardial ischemia rat model.Low dose Xuemailing (prepared fleece flower root) significantly decreased the elevation of 10 s,1 min ST segment and 10 s T wave of the rat model.High dose Xuemailing(raw radix polygoni multiflori) significantly decreased the elevation of 10 s ST segment and 10,45 s T wave in the rat model.Xuemailing (prepared fleece flower root) and Xuemailing (raw radix polygoni multiflori) significantly decreased LDH,CK,MDA enzyme activities,and increased SOD enzyme activities of the myocardial ischemia rat model. Conclusion Xuemailing can protect the myocardial ischemia rats induced by pituitrin.
