The research progress of neuregulin-1/ErbBs signaling in chronic heart failure
10.3969/j.issn.1001-1978.2017.11.001
- VernacularTitle:Neuregulin-1/ErbBs信号通路在慢性心力衰竭中的研究进展
- Author:
fei Qi ZHAO
1
;
Cong WEI
;
rong Hong LI
;
Hong REN
Author Information
1. 河北医科大学研究生学院
- Keywords:
neuregulin-1;
receptor tyrosine kinases;
cardiac myocyte apoptosis;
myocardial fibrosis;
ventricular remodeling;
chronic heart failure
- From:
Chinese Pharmacological Bulletin
2017;33(11):1481-1484
- CountryChina
- Language:Chinese
-
Abstract:
Neuregulin-1 (NRG-1) and the ErbBs family of receptor tyrosine kinases are widely expressed in the cardiovascular system.NRG-1/ErbBs signaling plays an essential role in physiology and pathophysiology of the heart,including stabilization of cardiac myocyte structure and function,promotion of cardiac myocyte proliferation and survival,inhibition of cardiac myocyte apoptosis,reduction of myocardial interstitial fibrosis,regulation of energy utilization,and enhancement of angiogenesis and so on.Therefore,NRG-1/ErbBs signaling is involved in the development and treatment of chronic heart failure(CHF).In this review,we bring the growing literature on NRG-1/ErbBs signaling and its significance in cardiovascular development and heart failure.
