Progression of related diseases of desmoglein abnormal and pharmacological intervention
10.3969/j.issn.1001-1978.2017.11.002
- VernacularTitle:桥粒芯糖蛋白表达和功能异常相关疾病及药物干预作用研究进展
- Author:
dan Yi ZHANG
1
;
sheng Qing YIN
;
han Shi GENG
;
xi Meng XU
;
wei Peng ZHUANG
;
jun Yan ZHANG
Author Information
1. 天津中医药大学中药药理学重点实验室
- Keywords:
desmoglein;
distribution;
skin tissue diseases;
disease of mucosa;
neoplasms;
pharmacological intervention
- From:
Chinese Pharmacological Bulletin
2017;33(11):1485-1489
- CountryChina
- Language:Chinese
-
Abstract:
Desmoglein,which is a kind of Ca2+ dependent desmosomal cadherins protein,is a major part of the desmosomes.The desmoglein that distributes in the epithelium,myocardium and other tissues plays a very important role in the cell junction.In recent years,the detection of the abnormal expression and function of the desmoglein was proved in many diseases,such as skin,mucous membrane and tumor related diseases.Drugs may have an important effect in the treatment of diseases by interfering with the expression and function of desmoglein.In this paper,the distribution of several subtypes of the family of desmosomes and their functions in the related diseases are reviewed,which may also provide some new clues for the new drug research on the target of desmogleins.
