The treatment of severe infection of mice caused by pandrug resistant Acinetobacter baumannii with bacteriophages
10.3969/j.issn.1002-2694.2017.10.014
- VernacularTitle:噬菌体治疗泛耐药鲍氏不动杆菌重症感染小鼠的研究
- Author:
xia Li YAN
1
;
cheng Zhi HUANG
;
pen Ying REN
;
mei Ke LI
;
wen Bao CHEN
;
zhi Guo WANG
Author Information
1. 浙江省台州市第一人民医院检验科
- Keywords:
bacteriophage;
treatment;
Acinetobacter baumannii;
infection
- From:
Chinese Journal of Zoonoses
2017;33(10):920-922
- CountryChina
- Language:Chinese
-
Abstract:
We explored the effect of therapy with bacteriophages for pandrug resistant Acinetobacter baumannii infections.Kunming mice (Specific Pathogen Free) were divided into two groups:experimental group (severe infection caused by pandrug resistant Acinetobacter baumannii) and the control group.The mice of experimental group were treated with Phages AB46 while the mice of control group were treated with broth.The survival rate was compared with statistical method and the spleen bacteria count was analyzed.Results showed that there were statistical difference between the experimental group and control group of Pandrug resistant Acinetobacter baumannii groups of 1 ∶ 10 dilution,P=0.020＜0.05.There were no statistical difference between each two groups of 1 ∶ 2 (P=0.650) and 1 ∶ 5 (P=0.170) dilution,both were＞0.05.There were no dead mice in groups of 1 ∶ 50 dilution with statistical difference of spleen bacteria count,P=0.026.Therapy with phages was an ef fective method to control infection caused by Pandrug resistant Acinetobacter baumannii which could increase the survival rate and decrease spleen bacteria count of the mice with light infection.
