Research progress of association between gene mutation and pyrazinamide resistance in Mycobacterium tuberculosis
10.3969/j.issn.1002-2694.2017.10.015
- VernacularTitle:结核分枝杆菌吡嗪酰胺耐药相关基因研究进展
- Author:
min Zhi CAO
1
;
Ling CHEN
Author Information
1. 遵义医学院刚属医院呼吸二科
- Keywords:
Mycobacterium tuberculosis;
pyrazinamide;
gene mutation;
drug resistance mechanism
- From:
Chinese Journal of Zoonoses
2017;33(10):923-926
- CountryChina
- Language:Chinese
-
Abstract:
Pyrazinamide (PZA) is an important anti-tuberculosis drug especially for treating multidrug-resistant tuberculo sis (MDR-TB).In recent years,the incidence of Mycobacterium tuberculosis' resistance to pyrazinamide has increased.At present,the mechanism of drug resistance has not been clearly elucidated.In this review,the association between gene mutation and pyrazinamide resistance in Mycobacterium tuberculosis will be summarized.
