BYHWD promotes endothelial progenitor cells to repair damaged vascu-lar endothelium

VernacularTitle:补阳还五汤促进内皮祖细胞修复损伤血管内皮
Author: Wei ZHANG ¹ ; Bing HE ; Liang LI ; Fei LI ; Lang CAO ; dan Xiao LIU ; qing Chang DENG
Author Information

1. 湖南中医药大学附属岳阳医院
Keywords: Buyanghuanwu decoction; Endothelial progenitor cells; Vascular endothelium; Endothelial nitric oxide synthase; Stromal cell-derived factor-1; CXC chemokine receptor-4
From: Chinese Journal of Pathophysiology 2017;33(11):1969-1974
CountryChina
Language:Chinese
Abstract: AIM:To investigate the role of Buyanghuanwu decoction(BYHWD) in promoting endothelial pro-genitor cells(EPCs)-induced recovery of damaged vascular endothelium. METHODS:The endothelial damaged rats were lavaged with BYHWD and injected with EPCs through vena caudalis. The repaired situation of damaged endothelium was observed. RESULTS:Compared with EPCs group and BYHWD group,the endothelial thickness was reduced, the levels of calcium,triglycerides and total cholesterol were decreased,but the high density lipoprotein levels were increased. In ad-dition,the protein expression of vascular endothelial nitric oxide synthase and vascular stromal cell-drived factor-1 was sig-nificantly increased,but the expression of CXC chemokine receptor-4 was significantly reduced in BYHWD+EPC group. CONCLUSION:BYHWD promotes EPCs repairing damaged endothelium,the mechanism may be related to improve the internal environment and promotes the EPCs homing.