Recent advances in the treatment of colorectal cancer liver metastases
10.3760/cma.j.issn.1007-8118.2017.10.020
- VernacularTitle:结肠癌肝转移的治疗进展
- Author:
Funian ZOU
1
;
Baifeng LI
Author Information
1. 中国医科大学附属第一医院肝胆外科
- Keywords:
Colorectal cancer;
Colorectal cancer liver metastases;
Chemotherapy;
Surgical treatment;
ALLPS;
Multidisciplinary team (MDT)
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(10):716-720
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the morbidity of colorectal cancer (CRC) has gradually increased,and trends to be younger.There are 1.2 million new patients suffering from CRC in the worldwide each year.Even undergoing radical mastectomy,there are still 25％ ～ 40％ of patients complicated with heterochronic liver metastasis simultaneously.The colorectal cancer liver metastasis (CRLM) has become one of the difficulties and the major cause of death,which is diagnosed in 20％ of patients at the same time of initial diagnosis.At present,the primary and metastatic cancer on liver resection is recognized as the only way to cure CRLM.In recent years,with the development of surgical technology,the normative use of peri-operative drugs,the collaboration of the mode of multidisciplinary team (MDT) and the development of the technology of targeted therapy,the survival rate of patients has been improved significantly.But the recurrence rate within 1 year is nearly 50 ％ after hepatectomy.Nearly 80 ％ of patients with CRLM missed opportunity for surgery when they were first diagnosed.Facing a huge group of CRLM,how to combine the patients' individual characteristics,the periodization of liver metastasis,the preoperative prognosis evaluation,the peri-operative adjuvant therapy and the directional treatment method etc.to form a systematic and effective therapeutic schedule has become the present focus attention,which still contains some outstanding issues.This article reviews the relevant progress.
