Research progress on genetic etiology of keratoconus
10.13389/j.cnki.rao.2017.0274
- VernacularTitle:圆锥角膜遗传病因学的研究进展
- Author:
Shuo RONG
1
;
Ying Chao WANG
;
Yan Bao HAN
;
Na Xiao LI
;
WeiYi CHEN
Author Information
1. 太原理工大学
- Keywords:
keratoconus;
etiology;
genetic factors
- From:
Recent Advances in Ophthalmology
2017;37(11):1083-1087
- CountryChina
- Language:Chinese
-
Abstract:
Keratoconus (KC) is a common cornea ectatic disorder characterized by myopia,irregular astigmatism and other visual impairment caused by corneal thinning and cone-shaped protrusion.With a wide range of effects,the etiology of this disease is unknown,and genetic factors may be involved in its pathogenesis.This paper summarizes the research progress on KC genetic etiology for reviewing the selected candidate genes and loci based on traditional/genome-wide linkage studies,genome-wide association studies and central corneal thickness in recent years.Genetic studies on KC pathogenesis will advance our understanding of this disease and further promote the development of potential therapies.
