Therapeutic limitations and strategies of angiogenesis inhibitors
10.3969/j.issn.1001-1978.2017.11.003
- VernacularTitle:肿瘤血管生成抑制剂的治疗局限和策略
- Author:
Wei WANG
1
;
yun Su YU
;
wei Jia WU
;
Shuai HUANG
;
yuan Yuan WU
;
xing Wen CHEN
;
yun Ai WANG
;
Yin LU
Author Information
1. 南京中医药大学药学院
- Keywords:
neoplasm;
angiogenesis inhibitors;
vascular normalization;
cancer stem cell;
precision therapy;
strategies
- From:
Chinese Pharmacological Bulletin
2017;33(11):1489-1492
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis inhibitors can make tumor cells in a harsh environment by inhibiting tumor angiogenesis and effectively blocking the tumor progression.However,anti-angiogenic drugs have shown lots of limitations,such as short-term duration,numerous adverse reactions,benefiting only a minority of tumor types and so on.These limitations restrain the development of new drugs and limit the cancer therapies.Many studies have revealed that tumor cells can escape from anti-angiogenic treatments through a variety of ways and mechanisms.In this review,we focus on the reasons behind the failure in treatments,so as to propose solving strategies to improve the current anti-angiogenic drug efficacy and provide reference for new angiogenesis inhibitors and clinical medication.
