Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice
- Author:
Dilruba SAYADA
1
;
Hasibuzzaman M. M.
;
Rahman MASHIUR
;
Mohanto Chandra NAYAN
;
Aktar SHARMIN
;
Rahman ATIQUR
;
Hossain Imam MD
;
Nikkon FARJANA
Author Information
1. Department of Biochemistry and Molecular Biology
- Keywords:
Sodium arsenite;
Raphanus sativus leaves;
Ameliorating effect;
Serum indices
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(10):915-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite(Sa)-induced adverse effects through mice experiments. Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase,and aspartate aminotransferase activities were significantly(P<0.05) higher in Sa-treated mice than those in the control group.RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P<0.05)prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels.RSL could also reduce the Sa-induced elevation of serum urea level significantly(P<0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic,cardiovascular and kidney dysfunction.Therefore,RSL may be useful to reduce arsenic toxicity in human in the future.
