Clinical analysis of 11 cases of urothelial carcinoma in the ipsilateral kidney transplant recipients
10.3760/cma.j.issn.0254-1785.2017.09.009
- VernacularTitle:肾移植后并发自体同侧上尿路上皮癌11例临床分析
- Author:
Zhanpo YANG
1
;
Wenhui ZHOU
;
Ziqiang XU
;
Qian LIU
;
Hongshun MA
Author Information
1. 300192,天津市第一中心医院
- Keywords:
Kidney transplantation;
Urological system;
Neoplasms
- From:
Chinese Journal of Organ Transplantation
2017;38(9):555-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristic,treatment,and prognosis of urological de novo malignant tumor in kidney transplant recipients.Methods A retrospective analysis was performed on 11 patients with urothelial carcinoma admitted in our institute between 2008 and 2016.Three patients were male and 8 patients were female.The interval between tumorigenesis and transplantation ranged from 12 to 132 months with a mean time of 68.4 months.Of the 11 cases,5 had pelvic TCC,4 cases had ureter TCC,and the rest 2 cases had pelvic and ureter TCC.All patients were in the same side of transplanted kidney (right).Of the 11 cases,7 had a main clinical manifestation of gross hematuria,3 cases had abdomen pain of the right side,and 1 case had hydronephosis of the right side during physical examination.Surgical treatment was taken in all 11 cases,combined with chemotherapy and irnmunotherapy (decreased immunosuppressive agents)treatment.Results Surgical treatment in all 11 cases was successful,and the postoperative pathology results confirmed the diagnosis of urothelial carcinoma.One patient receiving palliative treatment died 4 months after diagnosis.One patient died of extensive metastatic disease at 36th month postoperatively,and one patient died of respiratory failure.The rest 8 cases were followed for 4-96 months.One patient was given sirolimus (SRL) but diarrhea,so cyclosporine A (CsA) was administered.The renal function in the remaining 8 patients was normal.Conclusion Laparoscopic surgery combined with middle and small incision in the treatment of autologous ipsilateral urothelial carcinoma after renal transplantation is safe and effective.
