The prognostic significance of plasma Epstein-Barr virus DNA in patients with diffuse large B cell lymphoma

VernacularTitle:血浆EB病毒DNA在弥漫大B细胞淋巴瘤中的预后意义
Author: Na AN ¹ ; Yaping XIE ; Ying XU ; Pengfei SHI ; Shenxian QIAN
Author Information

1. 南京医科大学附属杭州医院
Keywords: Lymphoma; Epstein-Barr virus; Diffuse large B-cell lymphoma; Prognosis
From: Chinese Journal of Internal Medicine 2017;56(11):839-841
CountryChina
Language:Chinese
Abstract: To retrospectively analyze the prognostic significance of plasma Epstein -Barr virus (EBV) DNA in 122 patients with diffuse large B cell lymphoma (DLBCL).Plasma EBV DNA positivity was related to advanced disease stage ( P =0.030 ) , B symptoms ( P =0.004 ) and elevated serum lactic dehydrogenase (LDH) (P=0.001).Furthermore, univariate analysis indicated that plasma EBV DNA level was associated with worse overall survival (OS) (HR=0.223, 95%CI 0.096-0.518, P<0.001) and worse progression free survival (PFS) (HR =4.417, 95%CI 1.911 -10.208, P <0.001), whereas multivariate analysis showed plasma EBV DNA as a probable independent prognostic factor of clinical outcome(HR=0.409, 95%CI 0.166-1.008, P=0.052).