Analysis of Parental Decisions Based on Sex Chromosome Abnormalities Detected Prenatally: A Ten-year update (2001-2010).
- Author:
Gye Hyeong AN
1
;
Kyu Hong CHOI
;
Jae Hyug YANG
;
Moon Young KIM
;
Jung Yeol HAN
;
So Yeon PARK
;
Bom Yi LEE
;
Da Eun LEE
;
Hyun Mee RYU
Author Information
- Publication Type:Original Article
- Keywords: Sex chromosome aberration; Prenatal diagnosis; Genetic counseling
- MeSH: Family Characteristics; Fetus; Genetic Counseling; Humans; Mosaicism; Parents; Pregnancy; Prenatal Diagnosis; Reproductive Techniques; Sex Chromosome Aberrations; Sex Chromosomes; Specialization
- From:Journal of Genetic Medicine 2012;9(1):17-21
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The aim of this study was to analyze parental decisions regarding pregnancies in which the fetus had sex chromosome abnormalities (SCA) over a ten-year period. MATERIALS AND METHODS: We collected and reviewed records from our hospital for 2001-2010 and a genetic specialist provided-genetic counseling. RESULTS: We diagnosed 130 cases (0.71%) with SCA out of 18,376 prenatal cases from 2001 to 2010. We reviewed the records and the results of all pregnancies. We also included cases (n=84) of apparently normal anatomic fetuses to analyze the factors influencing parental decisions. We excluded 34 cases with an obvious anomaly or a presumably bad outcome and 12 cases that were not followed up. Forty-three couples (51.2%) continued their pregnancies while forty-one (48.8%) terminated them. Of 38 mosaicism cases, 21 (55.3%) were continued. Among the 20 pregnancies assisted by reproductive techniques, 15 (75%) were continued (P=0.02). More pregnancies were continued when genetic counseling was provided (61.9%) compared to cases in which it was not provided (19%) (P=0.01). CONCLUSION: Genetic counseling is important in providing appropriate information to parents. Establishing guidelines and protocols will help both obstetricians and parents to make informed decisions.
