The impact of goal directed analgesia on mechanical ventilated patients′s outcomes in intensive care unit:a clinical observational study
10.3760/cma.j.issn.0578-1426.2017.11.014
- VernacularTitle:目标化镇痛对ICU机械通气患者预后的影响
- Author:
Qingdong LI
1
;
Xianyao WAN
;
Yongli ZHANG
;
Suwei LI
;
Lili HAN
;
Wenwen LI
;
Huaying SHI
Author Information
1. 116011,大连 医科大学附属第一医院重症医学科大连医科大学重症医学研究所
- Keywords:
Analgesia;
Critical-care pain observation tool;
Respiration,artificial
- From:
Chinese Journal of Internal Medicine
2017;56(11):846-848
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the impact of goal directed analgesia on the outcome of patients with mechanical ventilation in intensive care unit. A total of 126 patients who needed mechanical ventilation were recruited. With a method of before and after paired comparison, they were divided into two group:( 1 ) analgesia with empirical administration or control group; ( 2 ) goal directed analgesia based on critical-care pain observation tool (CPOT). Compared with the control group, after goal directed analgesia was applied, the consumption of midazolam significantly dropped from ( 368. 47 ± 27. 41 ) mg to ( 151. 27 ± 29. 31 ) mg (P<0. 05), whereas the consumption of dexmedetomidine significantly increased from ( 623. 62 ± 20. 91) μg to (812. 34 ± 22. 57) μg(P<0. 05). The median score of Richmond agitation-sedation scale increased from -3 to -1. The incidence of delirium significantly reduced from 23. 81% to 17. 46%( P<0. 05). The mean ventilator duration was significantly shortened from (168. 49 ± 11. 41) h to (142. 38 ± 13. 24) h(P<0. 05). ICU length of stay was significantly shortened from (23. 64 ± 9. 26) d to (19. 63 ± 8. 46) d ( P < 0. 05 ) . Due to the mild sedation, patients receiving goal directed analgesia report less delirium, less ventilation time and shorter ICU length of stay, suggesting that the general outcome is improved.
