Advances on genome-wide association study in diagnosis and treatment of osteoporosis

VernacularTitle:全基因组关联研究在骨质疏松症诊疗中的进展
Author: Wei DENG ¹ ; Qingyao ZUO ; Jia CHEN
Author Information

1. 100035,北京积水潭医院内分泌科
Keywords: Osteoporosis; Genome-wide association study; Bone mineral density; Diagnosis
From: Chinese Journal of Laboratory Medicine 2017;40(11):848-851
CountryChina
Language:Chinese
Abstract: Osteoporosis is a complex disease caused by genetic and environmental factors,which the genetic architecture is not completely understood.Genome-wide association study(GWAS)have reformed the identification of genetic determinants of complex diseases including osteoporosis.In the past decade, more than 30 GWASes which were related to bone mass density identified nearly 100 independent loci.The bivariate GWAS approach is an effective approach to detect pleiotropic genes for two osteoporosis traits. However, genetic analyses must be combined with functional studies to understand the underlying mechanisms.The insight of bone metabolism by GWAS is of huge potential for the identification of novel drug targets for osteoporosis.