Hyperhomocysteinemia Promotes Renal Function Impairment in Patients with Chronic Stable Coronary Artery Disease
10.12007/j.issn.0258-4646.2017.07.006
- VernacularTitle:高同型半胱氨酸血症对慢性稳定性冠状动脉粥样硬化性心脏病患者肾功能的影响
- Author:
Yanhong SU
1
;
Hongmei ZHENG
;
Xu GUO
;
Xiaoou WANG
;
Xinzhong ZHANG
;
Daqing ZHANG
Author Information
1. 中国医科大学附属盛京医院心内科
- Keywords:
hyperhomocysteinemia;
inflammation;
renal dysfunction;
chronic stable artery disease
- From:
Journal of China Medical University
2017;46(7):600-603,608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible mechanism of hyperhomocysteinemia (HHcy) in renal dysfunction in patients with chronic stable coronary artery disease (SCAD).Methods We consequentially enrolled patients diagnosed as having SCAD and,according to homocysteine (Hcy) levels,divided them into the HHcy group (Hcy≥15 μmol/L,n =53) and control group (Hcy＜15 μmol/L,n =47).We further tested the relationship among plasma Hcy level,renal function,and serum levels of interleukin (IL)-6 and adiponectin (APN).Results IL-6 was significantly higher in the HHcy group than in the control group (P ＜ 0.05).However,APN level was obviously lower in the HHcy group than in the control group (P ＜ 0.05).Correlation analysis revealed that Hcy level positively correlated with creatinine (r =0.379,P ＜ 0.001),uric acid (r =0.238,P =0.019),cystatin C (r =0513,P ＜ 0.001),and IL-6 levels (r =0.561,P ＜ 0.001) but negatively correlated with estimated glomerular filtration rate (eGFR;r =-0.288,P =0.023) and APN level (r =-0.428,P ＜ 0.001).IL-6 level showed positive correlations with creatinine (r =0.406,P =0.002),uric acid (r =0.359,P =0.007),and cystatin C levels (r =0.387,P =0.007) but a negative correlation with eGFR (r =-0.370,P =0.005).Meanwhile,APN level showed negative correlations with creatinine (r =-0.694,P ＜ 0.001),uric acid (r =-0.420,P ＜0.001),and cystatin C levels (r =-0.553,P ＜ 0.001),but a positive correlation with eGFR (r =0.251,P =0.034).Conclusion Plasma Hcy level may have a predictive value for renal dysfunction in patients with SCAD.Moreover,HHcy probably promoted renal dysfunction by inducing the imbalance of anti-inflammation and pro-inflammation in patients with SCAD.
