Expression and significance of CD68 and TGF-β2 in benign prostatic hyperplasia
10.3760/j.issn.1000-6702.2017.z1.016
- VernacularTitle:CD68和转化生长因子-β2在良性前列腺增生组织中的表达及临床意义
- Author:
Haidong CAO
1
;
Dongwen WANG
;
Xiaoming CAO
;
Wei ZHANG
;
Xin WANG
;
Changjian ZHAO
Author Information
1. 山西医科大学第一医院泌尿外科
- Keywords:
Benign prostatic hyperplasia;
CD68;
Transforming growth factor-β2
- From:
Chinese Journal of Urology
2017;38(z1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of CD68 and TGF-β2 in benign prostatic hyperplasia(BPH).Methods The immunohistochemistry PV two step method was used to detect the expression level of CD68 and TGF-β2 in 90 cases of benign prostatic hyperplasia and combined with clinical data were analyzed.Results Positive rate of CD68 as macrophages marker was 86%(77/90) in the epithelial cells,positive rate of TGF-β2 as transforming growth factor marker was 79%(71/90) in epithelial cells and stromal cells. Immune inlfammation mediated by macrophages,with coloring degree deepening,the degree of immune inlfammation increased,larger prostate volume(P<0.01),IPSS score higher (P<0.01),maximum urinary lfow rate lower(P<0.01),the dffierences between groups were statistically significant.Conclusions This point may indicate immune inlfammation play an important role in the development process of BPH and help to complete the pathogenisis theory.
