Clinical study of CD64 combined with C-reactive protein and procalcitonin in the detection of neonatal sepsis
10.3760/cma.j.issn.1673-4912.2017.10.002
- VernacularTitle:CD64联合C-反应蛋白及降钙素原检测在新生儿败血症的临床研究
- Author:
Zheng YAN
1
;
Fan LIU
;
Fuzhong LIN
;
Yi WEI
;
Jun CHEN
;
Lifen ZHENG
;
Ting JIN
;
Shan LIN
;
Yuehua FANG
;
Hanqiang CHEN
Author Information
1. 350009,福建医科大学附属福州市第一医院儿科
- Keywords:
CD64;
C-reactive protein;
Procalcitonin;
Sepsis
- From:
Chinese Pediatric Emergency Medicine
2017;24(10):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of CD64 combined with C-reactive protein (CRP) and procalcitonin(PCT) in the diagnosis of neonatal sepsis.Methods A total of 70 neonates diag-nosed with neonatal sepsis(sepsis group),35 cases of non-infectious diseases(non-infected group),and 40 healthy newborns(healthy control group) were enrolled in the Department of Pediatrics,Fuzhou First Hospital Affiliated to Fujian Medical University from July 2015 to June 2016. Serum CD64 was detected by flow cytometry.Serum CRP and PCT were detected by automatic biochemical analyzer,and the results were com-pared and analyzed.Results The levels of serum CD64,CRP and PCT in sepsis group were significantly higher than those in non-infected group and healthy controls(P <0.05).The sensitivity and specificity of CD64 combined with CRP and PCT in the detection of neonatal sepsis were 97.14% and 96.00%,and the sensitivity and specificity in the combined detection were higher than those in three indicators alone.Conclusion CD64 combined with CRP and PCT in the detection of neonatal sepsis can improve the specificity,and provide the basis for early diagnosis.
