Clinical study on hyperbaric oxygen combined with cilostazol foot in treating diabetic foot
10.3969/j.issn.1673-4130.2017.21.006
- VernacularTitle:高压氧联合西洛他唑治疗糖尿病足的临床研究
- Author:
Guangying ZHANG
1
;
Wenying LUO
;
Tongwei HE
;
Yonggang ZU
;
Chengyu WANG
;
Yinghui GUO
Author Information
1. 廊坊市人民医院 内分泌科
- Keywords:
hyperbaric oxygen;
cilostazol;
diabetic foot;
HbA1c
- From:
International Journal of Laboratory Medicine
2017;38(21):2958-2960,2963
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicalvalue of hyperbaric oxygen combined with cilostazol in treating diabetic foot .Methods 90 patients with diabetic foot in our hospital from June 2014 to July 2016 were selected and randomly divided into the observation group and control group according to the random number table method ,45 cases in each group .The control group was given the cilostazol treatment on the basis of basic treatment ,while on the basis of control group treatment ,the observation group was added with the hyperbaric oxygen therapy .The clinical efficacy and the changes of hemorheology ,blood parameters and plasma fibrinolytic indicators of the two groups were observed .Results The total effective rate in the observation group was 91 .11% ,which was sig-nificantly higher than 71 .11% in the control group ,the difference was statistically significant(P<0 .05);the whole blood viscosity (high shear and low shear ) ,hematocrit after treatment in the observation group were significantly lower than those in the control group(P<0 .05);the levels of HbA1c ,homocysteine(Hcy) and plasma high-sensitivity C reactive protein(hs-CRP) after treatment in the observation group were significantly lower than those in the control group (P<0 .05) ,the levels of plasma fibrinogen andtis-sue-type plasminogen activator(TPA) after treatment in the observation group were significantly superior to those in the control group(P<0 .05) .Conclusion Hyperbaric oxygen combined with cilostazol can effectively improve the levels of HbA 1c ,Hcy and hs-CRP in thee patients with diabetic foot ,promotesthe wound healing and improves the clinical treatment effect .
