Clinical analysis on blood exchange transfusion in treating 142 cases of neonatal severe hyperbilirubinemia
10.3969/j.issn.1673-4130.2017.21.013
- VernacularTitle:换血治疗新生儿重度高胆红素血症142例临床分析
- Author:
Xiaoyou PENG
1
;
Jieying ZHOU
;
Shengtao LI
;
Wenyuan SHI
;
Xiangdong OUYANG
;
Youde CAO
Author Information
1. 湖南师范大学第一附属医院检验科
- Keywords:
hyperbilirubinemia;
causes constituents;
neonatal blood exchange transfusion therapy;
curative efficacy and safety
- From:
International Journal of Laboratory Medicine
2017;38(21):2977-2978,2981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cause constituents of neonatal severe hyperbilirubinemia and the clinical efficacy and safety of blood exchange transfusion treatment .Methods 142 neonates with severe hyperbilirubinemia conducted the blood exchange transfusion therapy .The levels of serum total bilirubin ,indirect bilirubin and direct bilirubin and the change of blood routine indica-tors were analyzed before and after blood exchange transfusion .Results The main causes leading to neonatal severe hyperbilirubi-nemia were bacterial infection(28 .20% ) ,glucose-6-phosphate dehydrogenase(G6PD) deficiency(27 .50% ) and pregnant women with ABO blood group incompatibility (16 .20% ) .The levels of serum total bilirubin ,indirect bilirubin ,direct bilirubin and blood routine indicators after operation in neonates with severe hyperbilirubinemia were significantly lower than those before operation , the differences were statistically significant (P<0 .05) .The total bilirubin swap exchange was (54 .40 ± 9 .90)% .The intraoperative adverse reactions rate was 3 .50% .The postoperative thrombocytopenia occurrence rate was 72 .00% .Conclusion The blood ex-change transfusion for treating neonatal severe hyperbilirubinemia possesses has clinical significance ,but the hematology and bio-chemical indicators monitoring should be strengthened for avoiding adverse reactions occurrence .
