Association between Nrf2 Gene rs35652124,rs6706649 and rs6721961 Polymorphism and Alzheimer's Disease
10.3969/j.issn.1671-7414.2017.05.017
- VernacularTitle:Nrf2基因启动子rs35652124,rs6706649和rs6721961位点单核苷酸多态性与阿尔茨海默病的相关性研究
- Author:
hua Bao ZHANG
1
;
Qi WU
Author Information
1. 安康市中医医院质控科
- Keywords:
alzheimer's disease;
NF-E2-related factor 2;
gene polymorphism
- From:
Journal of Modern Laboratory Medicine
2017;32(5):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic association between NF-E2-related factor 2 (Nrf2) gene polymorphism and Alzheimer's disease (AD) in the Han descent population of Shaanxi province.Methods 382 AD patients from January 2015 to December 2016 were recruited to participate in the study.According to age of onset,they were divided into the early-onset Alzheimer's disease (EOAD) group (116 cases) and the late-onset Alzheimer's disease (LOAD) group (266 cases).120 healthy volunteers without AD were recruited to participate in the study.Genotype was determined by polymerase chain reaction combined with DNA direct sequencing technique for the polymorphism of the Nrf2 gene.Results The genotype and allele distribution of rs35652124 and rs6721961 polymorphism were significantly different between the EOAD group and control group(P＜0.05).There was no significant difference of genotype and allele distribution of three Nrf2 gene single nucleotide polymorphisms (SNPs) between the LOAD group and control group (P＞ 0.05).For EOAD patients,age of onset was significantly different between different genotype of rs35652124 and rs6721961 (P＜0.05).However,there was no significant difference of age of onset in LOAD group(P＞0.05).Conclusion Polymorphism of the Nrf2 gene may associate with the risk of AD,and affect disease progression.
