Endoscopic ultrasonography-guided lauromacrogol ablation for pancreatic cystic neoplasms: a prospective study
10.3760/cma.j.issn.1007-5232.2017.09.009
- VernacularTitle:胰腺囊性肿瘤内镜超声引导下聚桂醇消融术的前瞻性研究
- Author:
Chen DU
1
;
Ningli CHAI
;
Enqiang LINGHU
;
Huikai LI
;
Yufa SUN
;
Wei XU
;
Zhenjuan LI
;
Lei JIANG
;
Lihua SUN
Author Information
1. 中国人民解放军总医院消化科
- Keywords:
Pancreatic neoplasms;
Endoscopy;
Ultrasonography;
Ablation;
Lauromacrogol
- From:
Chinese Journal of Digestive Endoscopy
2017;34(9):653-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and effectiveness of endoscopic ultrasonography (EUS)-guided ablation with lauromacrogol for pancreatic cystic neoplasms(PCNs). Methods A total of 38 patients with PCNs admitted to Chinese PLA General Hospital from April 2015 to March 2017 were prospectively enrolled to receive EUS-guided ablation with lauromacrogol. Adverse events, such as pancreatitis,fever,bleeding and abdominal pain, were monitored during and after the procedure. Patients were followed up with contrast-enhanced CT or MRI in 3 months,6 months,1 year and 2 year after ablation. Results Thirty-eight patients were enrolled in the study, and 8 of them underwent a second ablation;so, there were 46 treatments. There were 24 females and 14 males with mean age being 53.9±14.7 years. Mild acute pancreatitis occurred in 2 cases and moderate fever occurred in 1 case. The adverse events rate was 6.5%(3/46). Among the 29 patients with complete follow-up of 5 months(2-17 months), the medium tumor volume before operation was 7 564.40 mm3(301.38-87 082.87 mm3)while 542.84 mm3(0-18 202.58 mm3)after the operation(P=0.000). A total of 14 had complete remission(CR)and 8 had partial remission(PR)in 29 patients. The remission effective rate was 48.3%(14/29),40.0%(8/20)in the cysts of the head/uncinate and 66.7%(6/9)in the body/tail(P=0.353). The medium surface area of CR group seemed smaller than that of non-CR group(1 194.27 mm2VS 1 764.09 mm2, P=0.023). Conclusion EUS-guided ablation with lauromacrogol for PCNs is safe and effective. Cysts of smaller surface are more likely to be cured than larger ones.
