Application value of urine kidney injury molecule-1 in early evaluating the renal function for unilateral obstruction renal disease
10.3760/cma.j.issn.1673-4904.2017.11.005
- VernacularTitle:尿肾损伤分子-1对单侧梗阻性肾病肾功能早期评估的价值
- Author:
Zhiyong WANG
1
;
Li GUO
;
Hongyang LI
;
Xiuming LI
;
Qiang CHI
Author Information
1. 承德医学院附属医院泌尿外科
- Keywords:
Nephrosis;
Glomerular filtration rate;
Kidney function tests;
Kidney injury molecule-1
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(11):978-981
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the early renal function assessment value of urine kidney injury molecule-1(KIM-1)level in patients with unilateral obstruction renal diseases.Methods Seventy-eight patients with unilateral obstruction renal diseases were selected,and the glomerular filtration rate(GFR) was detected by 99Tcm-diethylene triaminepentaacetic acid (DTPA) renal dynamic imaging method. The patients were divided into 4 groups according to the GFR: normal renal function group with GFR>40 ml/(min·1.73 m2)25 cases(A group),low-injury renal function group with 20 ml/(min·1.73 m2)0.05).There was no statistical difference in serum creatinine and blood urea nitrogen among 5 groups (P>0.05). The KIM-1 was negatively correlated with GFR(r=-0.441,P<0.01),and the serum creatinine and blood urea nitrogen were not correlated with GFR (r = -0.115 and 0.019, P>0.05). The receiver operating characteristic curve analysis result showed that the area under curve of urine KIM-1 in the diagnosis of kidney injury was significantly higher than that in serum creatinine and blood urea nitrogen(0.804 vs.0.441 and 0.567);the sensitivity and specificity were 82.6% and 66.7%,56.5% and 53.3%,66.9% and 66.7%.Conclusions The expression level of urine KIM-1 of unilateral obstructive nephropathy with different degree of kidney injury is a higher sensitivity marker compared with serum creatinine and blood urea nitrogen, which is helpful for diagnosing kidney injury early in clinic.
