Study on clinical application of serum C-type natriuretic peptide ,IGF-Ⅱ ,ET ,NSE and S100B levels in craniocerebral trauma
10.3969/j.issn.1673-4130.2017.21.016
- VernacularTitle:血清CNP、IGF-Ⅱ、ET、NSE和S100B在颅脑外伤中的临床应用研究
- Author:
Zhihua WANG
1
;
Qingxi LIN
;
Pingxiang HUANG
;
Yangli ZHANG
;
Qinlin ZENG
;
Hongqin CHEN
;
Jingmei LI
Author Information
1. 解放军第92医院检验科
- Keywords:
craniocerebral trauma;
C-type natriuretic peptide;
insulin-like growth factor Ⅱ;
endothelin;
neuron-specific enolase;
S100B protein;
prognosis
- From:
International Journal of Laboratory Medicine
2017;38(21):2984-2987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of serum C-type natriuretic peptide (CNP) ,insulin-like growth factor II (IGF-Ⅱ ) , endothelin (ET) ,neuron-specific enolase (NSE) and S100B protein(S100B) on the prognosis of the patients with traumatic brain injury .Methods A total of 110 patients with craniocerebral trauma admitted in our hospital from January 2016 to January 2017 se-lected as the craniocerebral trauma group and further divided into the mild ,moderate and severe craniocerebral trauma groups ac-cording to the Glasgow Coma Scale (GCS) .Then the levels of serum CNP ,IGF-Ⅱ ,ET ,NSE and S100B in all cases were analyzed by enzyme-linked immunosorbent assay (ELISA) .Their influence on the prognosis of the patients with craniocerebral trauma and the correlation among various indicators were analyzed .Results The levels of CNP and IGF-Ⅱat admission in the craniocerebral trauma group were significantly decreased ,while the levels of ET ,NSE and S100B were significantly increased ,the difference com-pared with the control group was statistically significant (P<0 .05) .Serum CNP and IGF-Ⅱlevels in the death group ,plant survival group and disabled group were significantly decreased .The difference was statistically significant (P<0 .01) .Serum CNP and IGF-Ⅱlevels in the moderate and severe craniocerebral trauma groups were gradually increased with the disease course progress ,while serum ET ,NSE and S100B levels were gradually decreased with the disease course progress ,the difference was statistically signifi-cant(P<0 .05) .In the patients with craniocerebral trauma ,the positive correlation existed between CNP and IGF-Ⅱ ,between ET and S100B ,between ET and NSE ,and between NSE and S100B(P<0 .01) ,while the negative correlation existed between IGF-Ⅱand ET ,between IGF-Ⅱ and S100B ,between CNP and ET ,and between IGF-Ⅱand NSE (P<0 .01) .Conclusion Serum CNP , IGF-Ⅱ ,ET ,NSE and S100B are correlated to the severity of craniocerebral trauma ,which has a higher clinical application value for judging the disease condition ,evaluating the prognosis in cradiocerebral trauma .
