Efficacy and influential factors of post-resection 131 I therapy on metastases from differentiated thy- roid carcinoma
10.3760/cma.j.issn.2095-2848.2017.11.007
- VernacularTitle:分化型甲状腺癌术后131 I清灶疗效及影响因素分析
- Author:
Yanjun GUO
1
;
Xufu WANG
;
Guoqiang WANG
;
Cancan LIU
;
Yang SUN
;
Wenjuan ZHAO
Author Information
1. 266001,青岛大学附属医院内分泌与代谢病科
- Keywords:
Thyroid neoplasms;
Radiotherapy;
Iodine radioisotopes;
Treatment outcome
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(11):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and influential factors of post-resection 131 I thera-py in DTC patients with metastases can′t be removed by surgery. Methods A total of 112 DTC patients ( 41 males, 71 females, age range 8-80 years) with metastases from January 2012 to October 2016 in Affil-iated Hospital of Qingdao University were retrospectively analyzed. All patients underwent post-resection 131 I therapy, and the therapeutic effect was assessed. Univariate analysis (χ2 test, rank sum test) and the logis-tic regression analysis were performed to select the influential factors for treatment effect. The ROC curve a-nalysis of significant factors to predict the ineffectiveness of 131 I therapy was performed. Results Patients underwent single or repeated 131I therapy (1-9 times), and the effective rate was 75.89%(85/112). Univa-riate analysis showed that the tumor diameter, the location of metastasis, preablation sTg and sTg/TSH ratio were influential factors for 131 I therapy on metastases(χ2 values:7.187, 15.381;z values:-5.053,-5.187, all P<0.05) . Logistic regression analysis showed that the tumor diameter, preablation sTg were independent influential factors for 131 I therapy ( both P<0.05) . The areas under ROC curve for sTg, sTg/TSH ratio, and tumor diameter to predictive ineffectiveness were 0.824, 0.832, and 0.718, respectively. The cutoff values were 29.825μg/L, 0.298, 3.250 cm, respectively, the sensitivities were 92.60%, 96.30%, 40.70%, and the specificities were 62.40%, 55.30%, 91.80%. Conclusions The therapeutic effect of 131I therapy on metastases from DTC is significant. The longer tumor diameter, the distant metastasis, and the higher preab-lation sTg are negative influential factors for131 I therapy, which could be used to predict the therapeutic effect.
