Utility of 18 F-FDG PET/CT in early detection of radiation-induced heart disease in Beagle dogs
10.3760/cma.j.issn.2095-2848.2017.11.008
- VernacularTitle:18F-FDG PET/CT显像在早期诊断放射性心脏损伤中的应用
- Author:
Rui YAN
1
;
Jianbo SONG
;
Zhifang WU
;
Jianzhong LIU
;
Guoliang ZHANG
;
Xinzhong HAO
;
Sijin LI
Author Information
1. 山西医科大学护理学院
- Keywords:
Radiation injuries;
experimental;
Heart;
Positron-emission tomography;
Tomography;
X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(11):710-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish radiation-induced heart disease ( RIHD) Beagle models, in-vestigate the efficacy of 18 F-FDG PET/CT in the detection of RIHD and observe the pathological changes. Methods The ventricular anterior wall of 12 Beagle dogs were X-ray irradiated locally with a single dose of 20 Gy. 18 F-FDG PET/CT and echocardiography were performed at baseline and 3 months after radiation. ROI was drawn on the irradiation field and the non-irradiation field ( the posterior wall of left ventricle) to obtain the SUVmax . Then the SUVmax ratio of the irradiation field to the non-irradiation field ( INR) was cal-culated. The left ventricular function parameters before and after radiation were obtained by echocardio-graphy. Within 1 week after the imaging examinations were finished, the dogs were sacrificed, and hearts were taken out to perform pathological observation. Paired t test was used to analyze the data. Results High 18 F-FDG uptake in the irradiation field was shown 3 months after radiation. The average INRs before and after radiation were 0.99±0.15 and 2.54±0.43 respectively (t=7.021, P=0.001). No significant difference was ob-served on cardiac function parameters between baseline and 3 months after radiation( t values:from-1.253 to-0.786, all P>0.05) . The pathological results showed a few degenerated myocytes, increased thickness of myocardial vascular walls in irradiated myocardium. Conclusions 18 F-FDG PET/CT can detect early RIHD before abnormal cardiac function. Increased 18 F-FDG uptake in irradiated field may be related to myocardial ischemia which results from microvascular damage by radiation.
