Recent progress of 89 Zr tracers for PET imaging
10.3760/cma.j.issn.2095-2848.2017.11.016
- VernacularTitle:89Zr正电子显像剂的制备及进展
- Author:
Siyuan CHENG
1
;
Hao HONG
;
Xiaohua ZHU
Author Information
1. 华中科技大学同济医学院附属同济医院核医学科
- Keywords:
Radioactive tracers;
Zirconium;
Positron-emission tomography;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(11):733-737
- CountryChina
- Language:Chinese
-
Abstract:
89Zr is a positron-emitting metal with a long half-life (78.4 h) which is compatible to the labeling of slow-accumulating bioactive vectors. Many researchers have adopted 89 Zr for medical research. DFO is the most prevalent chelator used to link 89 Zr with bioactive vectors to synthesize stable PET agents, which gives high-resolution PET images with exceptional T/NT ratio. This review describes five methods based on DFO to synthesize 89 Zr-based PET agents, among which isothiocyanate ( Df-Bz-NCS) and N-succi-nyl-DFO ( N-suc-DFO) have been used in clinical studies. The targeting bioactive vectors labeled by 89 Zr for PET imaging include antibodies (monoclonal antibodies and their derivatives), polypeptides (RGD pep-tides), proteins (transferrin, albumin, etc.), bioengineering structures (nanoparticles, liposomes, micro-spheres, etc.), cells (stem cells, immune cell subsets) and so on. The application of 89Zr PET in drug de-velopment, cell tracking and tumor imaging has become increasingly prominent.
