LC-MS/MS application in pain management
10.3760/cma.j.issn.1009-9158.2017.10.018
- VernacularTitle:疼痛药物管理与液相-串联质谱技术的应用
- Author:
Zheng CAO
1
;
Yanhong ZHAI
;
He YANG
Author Information
1. 100026,首都医科大学附属北京妇产医院检验科
- Keywords:
Analgesics;
Drug monitoring;
Chromatography;
liquid;
Tandem mass spectrometry;
Pharmacy administration
- From:
Chinese Journal of Laboratory Medicine
2017;40(10):829-834
- CountryChina
- Language:Chinese
-
Abstract:
Pain management is the monitoring of chronic pain patients under long-term treatment with controlled analgesic drugs via random or regular lab tests. Plenty of clinical data showed that pain management could not only improve the patient′s compliance to prescribed drugs and result in better outcome,but also greatly reduce the possibility of controlled analgesic drugs into the underground market illegally. Drugs that are usually internationally recommended in pain management include opiates, opioids, sedative drugs, stimulant, hallucinogens etc. Considering drug metabolism rates difference among individuals and ease of sampling,random urine is usually the first choice of specimen for drug testing in pain management. In terms of methodology,LC-MS/MS has become a"gold standard"approach due to its high sensitivity,high specificity and wide usability.
