Improvement of Synthesis Technology for Sodium Picosulfate
10.6039/j.issn.1001-0408.2017.31.22
- VernacularTitle:匹可硫酸钠的合成工艺改进
- Author:
Jinrui SUN
1
;
Dan LI
;
Hongchen WANG
;
Yuxiao DENG
;
Li YANG
Author Information
1. 山东省药学科学院/山东省化学药物重点实验室
- Keywords:
Sodium picosulfate;
Synthesis technology;
4;
4′-(pyridin-2-ylmethylene)diphenol;
Improvement
- From:
China Pharmacy
2017;28(31):4404-4406
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To improve the synthesis technology of sodium picosulfate. METHODS:The synthesis technology of sodium picosulfate was improved by changing reaction solvent,charging sequence,refined method and formation of crystal water. Using phenol as raw material,it was condensed with 2-pyridinecarboxaldehyde to achieve 4,4′-(pyridin-2-ylmethylene)diphenol, and its yield rate was investigated. Sodium picosulfate was obtained after esterification,salification,formation of crystal water, and then its purity was determined. RESULTS:The yield rate of key intermediate 4,4′-(pyridin-2-ylmethylene) diphenol reached above 88%,and the purity of refined products reached over 99.5%. Sodium picosulfate monohydrate was stable,and the content of single impurity was less than 0.1%. CONCLUSIONS:The improved technology is simple with mild conditions,and suitable for large-scale production.
