Protective mechanism of GLP-1 on kidney in diabetic kidney disease patients
10.3969/j.issn.1006-6187.2017.10.022
- VernacularTitle:胰升血糖素样肽1对糖尿病肾脏疾病患者肾脏的保护作用机制
- Author:
Ke LI
1
;
Jiaqing SHAO
Author Information
1. 210002,南方医科大学南京临床医学院内分泌科
- Keywords:
Glucagon like peptide 1;
Diabetic kidney disease;
Protective mechanism
- From:
Chinese Journal of Diabetes
2017;25(10):957-960
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease is a common complication in patients with diabetes mellitus and so far,lacking effective therapy aiming at it.Glucagon like peptide-1 (GLP-1) receptor agonist is a novel hypoglycemic agent associated with incretin.Studies have shown that GLP-1 have additional renal protection independent of its hypoglycemic effect,mainly through the mechanisms such as antihypertension,reducing glomerular hyperfiltration,lowering proteinuria,anti-inflammatory,antioxidative stress and anti-RASS.In this review,we will summary their renal effects and mechanisms from the basic and clinical evidences.
