Role of cyclophilinD in induction of the regulated necrosis
10.3969/j.issn.1001-6325.2017.11.026
- VernacularTitle:亲环素D及其介导的调节性细胞坏死
- Author:
Shu GUO
1
;
Jun PENG
Author Information
1. 中南大学药学院药理学系
- Keywords:
cyclophilin D;
mPTP;
regulated necrosis;
cyclosporine A
- From:
Basic & Clinical Medicine
2017;37(11):1625-1628
- CountryChina
- Language:Chinese
-
Abstract:
CyclophilinD ( CypD) , a member of cyclophilins family displays a variety of biological function .CypD lo-cates in the mitochondrial matrix .As an component of mitochondrial permeability transition pore ( mPTP ) , CypD plays an important role in the regulating of mPTP opening , which leads to mitochondrial dysfunction and CypD-de-pendent regulated necrosis .Elucidation of the mechanisms of CypD in regulating mPTP and the regulated necrosis will provide novel insights in injury-relevant diseases , such as cardiac or cerebral ischemia .
