Research progress of sodium-dependent phosphate transporter in gout/hyperuricemia
10.3969/j.issn.1001-6325.2017.11.027
- VernacularTitle:钠依赖性磷酸转运蛋白在痛风/高尿酸血症中的研究进展
- Author:
Zhong WEN
1
;
guang Wen XIE
;
guo Jing ZHOU
Author Information
1. 川北医学院附属医院风湿免疫科
- Keywords:
uric acid;
hyperuricemia;
gout;
sodium-dependent phosphate cotransporter;
genetic polymorphism
- From:
Basic & Clinical Medicine
2017;37(11):1629-1633
- CountryChina
- Language:Chinese
-
Abstract:
Sodium-dependent phosphate cotransporter is encoded by the solute carrier family 17 gene.The gene is located on chromosome 6 and is an important transporter of the organic anion as the substrate and is expressed in kidney and other tissues .Among them, the sodium-dependent phosphate transporter type 1, 3, and 4 have the func-tion of transferring uric acid , and abnormal function can lead to the decrease of uric acid excretion , which can cause hyperuricemia and even induce gout .
