Intervention Effect of Zhuyun Ning RecipeⅡon Insulin Resistance and Inflammatory Factors in Threatened Abortion Patients with Polycystic Ovarian Syndrome
10.13359/j.cnki.gzxbtcm.2017.06.005
- VernacularTitle:助孕宁Ⅱ号对PCOS早孕先兆流产胰岛素抵抗及炎症因子的干预作用
- Author:
Xuan Xiao ZHAO
1
;
Lu CHEN
;
Xin LIU
;
Hua Zhi ZANG
;
Ling Xiao FENG
Author Information
1. 黑龙江中医药大学
- Keywords:
Zhuyun Ning RecipeⅡ;
polycystic ovarian syndrome;
insulin resistance;
threatened abortion;
spleen-kidney deficiency;
IL-18;
IL-10
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(6):810-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of Zhuyun Ning Recipe Ⅱ in treating spleen-kidney deficiency type of threatened abortion with polycystic ovarian syndrome(PCOS). Methods A total of 40 qualified outpatients and inpatients admitted in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were included into the study. Twenty patients diagnosed as spleen-kidney deficiency type of threatened abortion with PCOS complicated with insulin resistance (IR) were included into group A, 20 patients with spleen-kidney deficiency type of PCOS non-IR threatened abortion were included into group B,and 20 normal women with early pregnancy were included into group C. Groups A and B were given oral use of Zhuyun Ning RecipeⅡfor 30 days, and group C did not receive any medication. The scores of traditional Chinese medicine (TCM) symptoms, blood beta-human chorionic gonadotropin (β-HCG), serum progesterone, homeostatic model assessment for insulin resistance index(HOMA-IR), interleukin-18(IL-18), and interleukin-20(IL-20) of groups A and B were observed before and after treatment,and were compared to those of group C. Results (1)After treatment for 30 days,the observation indexes of group A were much improved(P < 0.05 or P < 0.01 compared with those before treatment), and the indexes in group B except for HOMA-IR were also improved (P < 0.05 or P < 0.01). The inter-group comparison showed that the differences of blood β-HCG, serum progesterone,and IL-10 were insignificant (P > 0.05);HOMA-IR and IL-18 levels in group A were higher than those in groups B and C, and the differences were significant (P < 0.01). However, the differences of HOMA-IR and IL-18 were insignificant between group B and group C (P > 0.05).(2)During the treatment, neither adverse reaction nor toxic or side effect was found.(3)The follow-up results showed that 5 cases of group A,2 cases of group B,and 4 cases of group C had full-term normal delivery,and the health state of newborn babies was quite well. One case of group A had pregnant diabetes at late pregnant stage,and the other patients of group A got through the middle and late pregnancy,without any pregnant complications. Conclusion Zhuyun Ning Recipe Ⅱ is effective on relieving symptoms of threatened abortion patients with PCOS,and can improve the related laboratory indexes and pregnancy outcomes of the patients.
