Optimization of Flash Extraction Technology for Guizhi Fuling Capsule by Box-Behnken Design-response Surface Method
10.6039/j.issn.1001-0408.2017.31.28
- VernacularTitle:Box-Behnken设计-响应面法优化桂枝茯苓胶囊的闪式提取工艺
- Author:
Zhengkuan WANG
1
;
Yuan LIU
;
Xiaomeng SHI
;
Zhenzhong WANG
;
Wei XIAO
Author Information
1. 江苏康缘药业股份有限公司康缘现代中药研究院
- Keywords:
Guizhi fuling capsule;
Single factor test;
Box-Behnken design;
Response surface method;
Flash extraction;
Tech-nology extraction
- From:
China Pharmacy
2017;28(31):4429-4433
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the flash extraction technology for Guizhi fuling capsule. METHODS:Using blade speed,liquid-solid ratio,extraction time as investigation factors,using the comprehensive evaluation values consisting of transfer rates of gallic acid,paeoniflorin,benzoic acid,cinnamic acid,benzoyl paeoniflorin,amygdalin as investigation index,single fac-tor test was combined with Box-Behnken design-response surface method to optimize the flash extraction technology for Guizhi ful-ing capsule. Verification test was conducted and compared with conventional decoction extraction method(extracting twice,totally 240 min). RESULTS:The optimal flash extraction technology for Guizhi fuling capsule was using water as extraction solvent with blade speed of 5600 r/min and liquid-solid ratio of 10.5:1,extracting for 60 s. The average comprehensive evaluation value of veri-fication test was 85.40%(n=3),with relative error of 0.15% to the predicted value(85.55%),higher than decoction extraction method(72.65%). CONCLUSIONS:Optimized flash extraction technology for Guizhi fuling capsule is efficient and rapid.
