Research advances in the role of long non-coding RNA in diabetic kidney disease
10.3969/j.issn.1006-6187.2017.10.018
- VernacularTitle:长链非编码RNA在糖尿病肾脏疾病中作用机制的研究进展
- Author:
Yanlin YANG
1
;
yijie JIA
;
Yaoming XUE
Author Information
1. 南方医科大学南方医院内分泌代谢病科
- Keywords:
Long-non-coding RNA;
Diabetic kidney disease;
Biomarker
- From:
Chinese Journal of Diabetes
2017;25(10):942-945
- CountryChina
- Language:Chinese
-
Abstract:
Objective Long non-coding RNA(lncRNA),with more than 200 nucleotides in length,is closely related to many endocrine and metabolic diseases as a functional RNA.Researches has shown that lncRNA can regulate gene expression in multiple levels,including participation in chromatin imprints,in combination with apparent modified complexes or transcription factors to play a transcriptional regulation,and binding with miRNA,mRNA or protein to play the role of post-transcriptional regulation.The disorder of lncRNA expression and the mutation of the primary sequence or variation of the secondary structure are associated with many human diseases.The study of lncRNA in diabetic kidney disease is still in its infancy.In addition,since some lncRNA can be detected in human body fluid and have good specificity and accessibility,it is speculated that lncRNA can be used as a new potential biomarker for the diagnosis and prognosis of diabetic kidney disease.
